Main Article Content


The current work aimed to study the effects of Ciprofloxacin (80mg/kg body weight) on levels of lipids (Cholesterol, Triglycerides, HDL, VLDL, and LDL) and liver enzymes (GOT, GPT, and Alkaline phosphatase) in albino mice for 3, 7 and 14 days using ∆pH/30 min method. The study was conducted by dividing the albino mice into four equal groups. G-I: control group, G-II: animals were treated with ciprofloxacin as one /day orally for 3 days, G-III: animals were treated with ciprofloxacin as one per/day orally for 7 days, and G-IV: animals were treated with ciprofloxacin one per/day orally for 14 days. The results showed that ciprofloxacin therapy raised the blood total cholesterol considerably and serum HDL, LDL, GOT, GPT, and Alkaline phosphatase significantly. There was a substantial decrease in triglyceride levels in the blood. 


Parasitic contamination Vegetable Worm, Protozoan

Article Details

How to Cite
ATALLAH, A. H., AL MASAOODI, N. N., & ALMOSAWY, W. (2022). The effect of ciprofloxacin on the lipids and some liver enzymes in albino mice. Iranian Journal of Ichthyology, 9, 176–179. Retrieved from


    Adikwu, E. & Brambaifam, N. 2012. Ciprofloxacin cardio- toxicity and hepatoxicity in human and animals. Pharmacology 3: 207-213.
    AL-Rikaby, A.A.; Ghadhban, R.F. & Majeed, S.K. 2016. The effects of ciprofloxacin on male rabbits: Biochemical and histopathological study. Al-Qadisiyah Journal of Veterinary Medicine Sciences 15(1): 38-44.
    Aqeel, H. & Atallah, A. 2021. Study the Effect of Ciprofloxacin on Cholinesterase in Different Organs of Mice. Iraqi Journal of Science 56(2A): 21456
    Belfield D.M. 1971. Goldberg, colorimetric determination of alkaline phosphatase activity. Enzyme 12(5): 561-568.
    Bergan, T.; Thorsteinsson, S.B.; Solberg, R.; Bjornskau, L.; Kolstad, I.M. & Johnson S. 1987. Pharmacokinetics of ciprofloxacin: intravenous and increasing oral doses. American Journal of Medicine 82: 97-102.
    Bertino Jr, J. & Fish, D. 2000. The safety profile of the fluoroquinolones. Clinical therapeutics 22(7): 798-817.
    Chalasani, N.; Fontana, R.J.; Bonkovsky, H.L.; Watkins, P.B.; Davern, T. & Serrano, J. 2000. Drug induced liver injury network (DILIN) causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology 135(6): 1924-1934.
    Dana, E.K.; Robb, M. & Sandra, H.L. 2001. New classification and update on the quinolone antibiotics. Amer. Fam. Physic.
    Dufour, R.; Lott, J.; Nolte, F.; Greth, D.; Koff, R. & Seef, L. 2000. Dignosis and monitoring of hepatic injury performance characteristic of laboratory test. Clinical Chemistry 46: 2027-2068.
    Food and Drug Administration. 2005. Estimating the safe starting dose in clinical trials for therapeutics in adult healthy volunteers. Rockville, Maryland, USA: US: Food and Drug Administration.
    Friedewald, W.T.; Levy, R.T. & Frederickson, D.S. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge Clinical Chemistry 18: 499-502.
    Gordon, T.; Castelli, W.P.; Hjortland, M.C.; Kannel, W.B. & Dawber, T.R. 1977. High density lipoprotein as a protective factor against coronary heart disease: the Framingham Study. The American Journal of Medicine 62(5): 707-714.
    Hyeon, C.K.; Chung, M.N.; Sun, H.J.; Kwang, H.H.; Oh, D.K. & Suh, I. 2004. Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study. BMJ 328(7446): 983.
    Liu, Q. & Wong, J.C. 1999. Similarity in the catalysis of DNA breakage and rejoining by type IA and IIA DNA topoisomerase. Proceedings of the National Academy of Sciences 96: 881-886.
    Qutrio Baloch, Z.; Raza, M.A. & Abbas, S.A. 2017. Ciprofloxacin-induced Hepatotoxicity in a Healthy Young Adult. Cureus 9: e1016.
    Reitman, S. & Frankel, S. 1957. A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases. American Journal of Clinical Pathology 28: 56-63.
    Rosenthal, P. 1997. Assessing liver function and Hyperbilirubinemia in the newborn. Clinical Chemistry 43(1): 228-234.
    Schettler, G. & Nussel, E. 1975. Determination of serum total cholesterol by enzymatic Colorimetric test. Arbeitsmedizin, Sozialmedizin, Präventivmedizin Sonderheft 10: 25.
    Widmaier, E.P.; Raff, H. & Strang, K.T. 2006. Vander’s Human Physiology, the Mechanisms of Body Function. 10th ed., McGraw-Hill, pp. 575-583.
    Zimmerman, H.J. 2000. Drug-induced liver disease. Clinics in Liver Disease 4.1(2000): 73-96.