Main Article Content
Abstract
The present work was conducted to study the effect of ibuprofen (IBU) on histological parameters of male rats' liver for 30 and 60 days following oral administration. Fifty albino male rats are used in this study and they divided into five treatments each including five rats as control group, group administrated with 10mg/kg/day, group administrated with 20mg/kg/day, group administrated with 30mg/kg/day and group administrated with 40mg/kg/day of ibuprofen. The male rats were randomly divided into two main groups, comprising twenty-five rats for each group. The first main group was treated for 30 days and the second main group for 60 days. The animals were treated for 30 and 60 days following oral administration of 10, 20, 30, and 40mg/kg/day. The histological sections of the liver of the treatments at doses of 10, 20, 30, and 40mg/kg/day for 30 and 60 days showed high histopathological changes and their severity had raised by increasing concentration and exposure time.
Keywords
Drug
Histology
NSAID
Anti-inflammatory
Article Details
License
The authors transfer the copyrights of their papers to the Iranian Society of Ichthyology. However, the information could be used in accordance with the Creative Commons licence (Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
How to Cite
HADI, W. H., & ABOOD, A. H. (2022). Effect of ibuprofen on histological parameters of the liver in male albino rats. Iranian Journal of Ichthyology, 9, 234–240. Retrieved from http://www.ijichthyol.org/index.php/iji/article/view/804
References
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Adebambo, K.F. & Haji, N. 2021. Molecular Docking Study of the Binding Interaction of Hydroxychloroquine, Dexamethasone and Other Anti-Inflammatory Drugs with SARS-CoV-2 Protease and SARS-CoV-2 Spikes Glycoprotein. Computational Molecular Bioscience 11(2): 19-49.
Al-Tameemi, W.; Dunnill, C.; Hussain, O.; Komen, M.M.; van den Hurk, C.J.; Collett, A. & Georgopoulos, N.T. 2014. Use of in vitro human keratinocyte models to study the effect of cooling on chemotherapy drug-induced cytotoxicity. Toxicology in Vitro 28(8): 1366-1376.
Degirmenci, A.L.P.İ.N. & Yalcin, E. 2019. The effect of pregabalin and ibuprofen combination for pain after third molar surgery. Nigerian Journal of Clinical Practice 22(4): 503.
González-Ponce, H.A.; Rincón-Sánchez, A.R.; Jaramillo-Juárez, F. & Moshage, H. 2018. Natural dietary pigments: potential mediators against hepatic damage induced by over-the-counter non-steroidal anti-inflammatory and analgesic drugs. Nutrients 10(2): 117.
Hale, T.W. 2020. Hale's Medications & Mothers' Milk TM 2021: A Manual of Lactational Pharmacology. Springer Publishing Company.
Hočevar, A.; Ješe, R.; Rotar, Ž. & Tomšič, M. 2019. Does leflunomide have a role in giant cell arteritis? An open-label study. Clinical Rheumatology 38(2): 291-296.
Ivshina, I.B.; Tyumina, E.A.; Bazhutin, G.A. & Vikhareva, E.V. 2021. Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen. PloS one 16(11): e0260032.
Litchfield, M. 2020. Molecular imaging of cyclooxygenase-2 (COX-2) and autotaxin (ATX) in cancer using positron emission tomography (PET).
Mesripour, A. & Gasemi, F. 2021. The NSAIDs Ibuprofen and Celecoxib and the TNF-α Blocker Etanercept Prevented Cyclosporine A-Induced Depression-Like Behavior in Mice. Hacettepe University Journal of the Faculty of Pharmacy 41(3): 133-142.
Mohammed, N.M.; El-Drieny, E.; Ibrahim, S.; Al-agory, M. & Gheth, E.M. 2019. Histopathological Changes in liver tissue induced by meloxicam in male mice. International Journal of Pharmacy and Life Sciences 10(1): 6059-6063.
Mulkiewicz, E.; Wolecki, D.; Świacka, K.; Kumirska, J.; Stepnowski, P. & Caban, M. 2021. Metabolism of non-steroidal anti-inflammatory drugs by non-target wild-living organisms. Science of the Total Environment 148251.
Obayes, A.K. 2019. Histological assessment for the effect of perineural injection of Botulinum toxin A (Botox) in the Rabbits and White Rats, Doctoral dissertation, Tikrit University.
Ogunwole, G.A.; Saliu, J.K.; Osuala, F.I. & Odunjo, F.O. 2021. Chronic levels of ibuprofen induces haematoxic and histopathology damage in the gills, liver, and kidney of the African sharptooth catfish (Clarias gariepinus). Environmental Science and Pollution Research 1-11.
Pirat, C.; Farce, A.; Lebègue, N.; Renault, N.; Furman, C.; Millet, R. & Chavatte, P. 2012. Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. Journal of Medicinal Chemistry 55(9): 4027-4061.
Rainsford, K.D. 2013. Ibuprofen: from invention to an OTC therapeutic mainstay. International Journal of Clinical Practice 67: 9-20.
Tu, J.; Huang, W.; Zhang, W.; Mei, J. & Zhu, C. 2021. A tale of two immune cells in rheumatoid arthritis: the crosstalk between macrophages and T cells in the synovium. Frontiers in Immunology 12: 2359.
Upadhyay, A.; Amanullah, A.; Joshi, V.; Dhiman, R.; Prajapati, V.K.; Poluri, K.M. & Mishra, A. 2021. Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases. Drug Metabolism Reviews 53(1): 100-121.
Wen, C.; Zhuang, Z.; Song, H.; Tong, S.; Wang, X.; Lin, Y. & Hu, L. 2018. Metabolism of liver CYP450 and ultrastructural changes after long-term administration of aspirin and ibuprofen. Biomedicine and Pharmacotherapy 108: 208-215.
Xie, X.L.; He, J.T.; Wang, Z.T.; Xiao, H.Q.; Zhou, W.T.; Du, S.H. & Wang, Q. 2018. Lactulose attenuates METH-induced neurotoxicity by alleviating the impaired autophagy, stabilizing the perturbed antioxidant system and suppressing apoptosis in rat striatum. Toxicology Letters 289: 107-113.
Zoubek, M.E.; Woitok, M.M.; Sydor, S.; Nelson, L.J.; Bechmann, L.P.; Lucena, M. I. & Cubero, F.J. 2019. Protective role of c‐Jun N‐terminal kinase‐2 (JNK2) in ibuprofen‐induced acute liver injury. The Journal of Pathology 247(1): 110-122.
References
Adebambo, K.F. & Haji, N. 2021. Molecular Docking Study of the Binding Interaction of Hydroxychloroquine, Dexamethasone and Other Anti-Inflammatory Drugs with SARS-CoV-2 Protease and SARS-CoV-2 Spikes Glycoprotein. Computational Molecular Bioscience 11(2): 19-49.
Al-Tameemi, W.; Dunnill, C.; Hussain, O.; Komen, M.M.; van den Hurk, C.J.; Collett, A. & Georgopoulos, N.T. 2014. Use of in vitro human keratinocyte models to study the effect of cooling on chemotherapy drug-induced cytotoxicity. Toxicology in Vitro 28(8): 1366-1376.
Degirmenci, A.L.P.İ.N. & Yalcin, E. 2019. The effect of pregabalin and ibuprofen combination for pain after third molar surgery. Nigerian Journal of Clinical Practice 22(4): 503.
González-Ponce, H.A.; Rincón-Sánchez, A.R.; Jaramillo-Juárez, F. & Moshage, H. 2018. Natural dietary pigments: potential mediators against hepatic damage induced by over-the-counter non-steroidal anti-inflammatory and analgesic drugs. Nutrients 10(2): 117.
Hale, T.W. 2020. Hale's Medications & Mothers' Milk TM 2021: A Manual of Lactational Pharmacology. Springer Publishing Company.
Hočevar, A.; Ješe, R.; Rotar, Ž. & Tomšič, M. 2019. Does leflunomide have a role in giant cell arteritis? An open-label study. Clinical Rheumatology 38(2): 291-296.
Ivshina, I.B.; Tyumina, E.A.; Bazhutin, G.A. & Vikhareva, E.V. 2021. Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen. PloS one 16(11): e0260032.
Litchfield, M. 2020. Molecular imaging of cyclooxygenase-2 (COX-2) and autotaxin (ATX) in cancer using positron emission tomography (PET).
Mesripour, A. & Gasemi, F. 2021. The NSAIDs Ibuprofen and Celecoxib and the TNF-α Blocker Etanercept Prevented Cyclosporine A-Induced Depression-Like Behavior in Mice. Hacettepe University Journal of the Faculty of Pharmacy 41(3): 133-142.
Mohammed, N.M.; El-Drieny, E.; Ibrahim, S.; Al-agory, M. & Gheth, E.M. 2019. Histopathological Changes in liver tissue induced by meloxicam in male mice. International Journal of Pharmacy and Life Sciences 10(1): 6059-6063.
Mulkiewicz, E.; Wolecki, D.; Świacka, K.; Kumirska, J.; Stepnowski, P. & Caban, M. 2021. Metabolism of non-steroidal anti-inflammatory drugs by non-target wild-living organisms. Science of the Total Environment 148251.
Obayes, A.K. 2019. Histological assessment for the effect of perineural injection of Botulinum toxin A (Botox) in the Rabbits and White Rats, Doctoral dissertation, Tikrit University.
Ogunwole, G.A.; Saliu, J.K.; Osuala, F.I. & Odunjo, F.O. 2021. Chronic levels of ibuprofen induces haematoxic and histopathology damage in the gills, liver, and kidney of the African sharptooth catfish (Clarias gariepinus). Environmental Science and Pollution Research 1-11.
Pirat, C.; Farce, A.; Lebègue, N.; Renault, N.; Furman, C.; Millet, R. & Chavatte, P. 2012. Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. Journal of Medicinal Chemistry 55(9): 4027-4061.
Rainsford, K.D. 2013. Ibuprofen: from invention to an OTC therapeutic mainstay. International Journal of Clinical Practice 67: 9-20.
Tu, J.; Huang, W.; Zhang, W.; Mei, J. & Zhu, C. 2021. A tale of two immune cells in rheumatoid arthritis: the crosstalk between macrophages and T cells in the synovium. Frontiers in Immunology 12: 2359.
Upadhyay, A.; Amanullah, A.; Joshi, V.; Dhiman, R.; Prajapati, V.K.; Poluri, K.M. & Mishra, A. 2021. Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases. Drug Metabolism Reviews 53(1): 100-121.
Wen, C.; Zhuang, Z.; Song, H.; Tong, S.; Wang, X.; Lin, Y. & Hu, L. 2018. Metabolism of liver CYP450 and ultrastructural changes after long-term administration of aspirin and ibuprofen. Biomedicine and Pharmacotherapy 108: 208-215.
Xie, X.L.; He, J.T.; Wang, Z.T.; Xiao, H.Q.; Zhou, W.T.; Du, S.H. & Wang, Q. 2018. Lactulose attenuates METH-induced neurotoxicity by alleviating the impaired autophagy, stabilizing the perturbed antioxidant system and suppressing apoptosis in rat striatum. Toxicology Letters 289: 107-113.
Zoubek, M.E.; Woitok, M.M.; Sydor, S.; Nelson, L.J.; Bechmann, L.P.; Lucena, M. I. & Cubero, F.J. 2019. Protective role of c‐Jun N‐terminal kinase‐2 (JNK2) in ibuprofen‐induced acute liver injury. The Journal of Pathology 247(1): 110-122.
Al-Tameemi, W.; Dunnill, C.; Hussain, O.; Komen, M.M.; van den Hurk, C.J.; Collett, A. & Georgopoulos, N.T. 2014. Use of in vitro human keratinocyte models to study the effect of cooling on chemotherapy drug-induced cytotoxicity. Toxicology in Vitro 28(8): 1366-1376.
Degirmenci, A.L.P.İ.N. & Yalcin, E. 2019. The effect of pregabalin and ibuprofen combination for pain after third molar surgery. Nigerian Journal of Clinical Practice 22(4): 503.
González-Ponce, H.A.; Rincón-Sánchez, A.R.; Jaramillo-Juárez, F. & Moshage, H. 2018. Natural dietary pigments: potential mediators against hepatic damage induced by over-the-counter non-steroidal anti-inflammatory and analgesic drugs. Nutrients 10(2): 117.
Hale, T.W. 2020. Hale's Medications & Mothers' Milk TM 2021: A Manual of Lactational Pharmacology. Springer Publishing Company.
Hočevar, A.; Ješe, R.; Rotar, Ž. & Tomšič, M. 2019. Does leflunomide have a role in giant cell arteritis? An open-label study. Clinical Rheumatology 38(2): 291-296.
Ivshina, I.B.; Tyumina, E.A.; Bazhutin, G.A. & Vikhareva, E.V. 2021. Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen. PloS one 16(11): e0260032.
Litchfield, M. 2020. Molecular imaging of cyclooxygenase-2 (COX-2) and autotaxin (ATX) in cancer using positron emission tomography (PET).
Mesripour, A. & Gasemi, F. 2021. The NSAIDs Ibuprofen and Celecoxib and the TNF-α Blocker Etanercept Prevented Cyclosporine A-Induced Depression-Like Behavior in Mice. Hacettepe University Journal of the Faculty of Pharmacy 41(3): 133-142.
Mohammed, N.M.; El-Drieny, E.; Ibrahim, S.; Al-agory, M. & Gheth, E.M. 2019. Histopathological Changes in liver tissue induced by meloxicam in male mice. International Journal of Pharmacy and Life Sciences 10(1): 6059-6063.
Mulkiewicz, E.; Wolecki, D.; Świacka, K.; Kumirska, J.; Stepnowski, P. & Caban, M. 2021. Metabolism of non-steroidal anti-inflammatory drugs by non-target wild-living organisms. Science of the Total Environment 148251.
Obayes, A.K. 2019. Histological assessment for the effect of perineural injection of Botulinum toxin A (Botox) in the Rabbits and White Rats, Doctoral dissertation, Tikrit University.
Ogunwole, G.A.; Saliu, J.K.; Osuala, F.I. & Odunjo, F.O. 2021. Chronic levels of ibuprofen induces haematoxic and histopathology damage in the gills, liver, and kidney of the African sharptooth catfish (Clarias gariepinus). Environmental Science and Pollution Research 1-11.
Pirat, C.; Farce, A.; Lebègue, N.; Renault, N.; Furman, C.; Millet, R. & Chavatte, P. 2012. Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. Journal of Medicinal Chemistry 55(9): 4027-4061.
Rainsford, K.D. 2013. Ibuprofen: from invention to an OTC therapeutic mainstay. International Journal of Clinical Practice 67: 9-20.
Tu, J.; Huang, W.; Zhang, W.; Mei, J. & Zhu, C. 2021. A tale of two immune cells in rheumatoid arthritis: the crosstalk between macrophages and T cells in the synovium. Frontiers in Immunology 12: 2359.
Upadhyay, A.; Amanullah, A.; Joshi, V.; Dhiman, R.; Prajapati, V.K.; Poluri, K.M. & Mishra, A. 2021. Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases. Drug Metabolism Reviews 53(1): 100-121.
Wen, C.; Zhuang, Z.; Song, H.; Tong, S.; Wang, X.; Lin, Y. & Hu, L. 2018. Metabolism of liver CYP450 and ultrastructural changes after long-term administration of aspirin and ibuprofen. Biomedicine and Pharmacotherapy 108: 208-215.
Xie, X.L.; He, J.T.; Wang, Z.T.; Xiao, H.Q.; Zhou, W.T.; Du, S.H. & Wang, Q. 2018. Lactulose attenuates METH-induced neurotoxicity by alleviating the impaired autophagy, stabilizing the perturbed antioxidant system and suppressing apoptosis in rat striatum. Toxicology Letters 289: 107-113.
Zoubek, M.E.; Woitok, M.M.; Sydor, S.; Nelson, L.J.; Bechmann, L.P.; Lucena, M. I. & Cubero, F.J. 2019. Protective role of c‐Jun N‐terminal kinase‐2 (JNK2) in ibuprofen‐induced acute liver injury. The Journal of Pathology 247(1): 110-122.