Main Article Content
Abstract
The current study was conducted to evaluate the healing aspect of skin fish collagen on the infected wound in local rabbits. A total of 16 mature animals were divided equally as control and treated groups. Lidocaine 2 % subcutaneously was used as a local anesthetic at the operative site, followed by surgical incision bout 3*4 cm induced full skin wound. Then, the wounds were contaminated with Staphylococcus aureus. After 24hr to 7 days of treatments, the results of temperature, respiration, and heart rates showed a significant difference between the two groups. Furthermore, the photographic scar aggregation in treated groups’ wounds appears less than in the control one. The histological results of the skin biopsies on the seventh and 21st days postoperative in the control group revealed extensive tissue necrosis and hemorrhage, and highly cellular granulation tissue, respectively. Whereas in the treated group on the 7th-day and 21st days post-operation, the histopathological sections revealed good epithelization with early granulation tissue formation characterized, excellent epithelization with a small amount of keratin on the surface, respectively. It was concluded that common carp skin collagen has a good therapeutically antibacterial and anti-inflammatory effect in wound healing.
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The authors transfer the copyrights of their papers to the Iranian Society of Ichthyology. However, the information could be used in accordance with the Creative Commons licence (Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
References
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Nakajima, J.; Sasaki, A.; Toru-obuchi, T.; Baba, S.; Nittaand, H. & Wakabayashi, C. 2009. Laparoscopic Subtotal Cholecystactomy for severe Cholecystitis. Surgery Today 39(10): 870-875
Tokajian, S. 2014. New epidemiology of Staphylococcus aureus infections in the Middle East. Clinical Microbiology and Infection 20(7): 624-628.
Verma, G.R.; Lyngdoh, T.S. & Kaman, L. 2006. Placement of 0.5% bupivacaine-soaked surgical in the gallbladder bed is effective for pain after laparoscopic cholecystectomy. Surgical Endoscopy 20: 1560-1564.
References
Axe, J. 2021. Fish collagen: The Anti-Aging Protein with the Best Bioavailability, Ancient Remedies. Little Brown Spark; 1st edition.
Costa, B.A.; Junior, E.M.L.; Filho, M.O.D.; Fechine, F.V.; De Moraes, M.E.A.; Junior, F.R.S.; Soares, M.F.A.D. & Rocha, M.B.S. 2019. Use of tilapia skin as a xenograft for pediatric burn treatment: a case report. Journal of Burn Care and Research 40: 714-7.
Dizerega G.S. 1994. Contemporary adhesion prevention. Fertility and Sterility 61: 219-235.
Ekawati, E.R.; Darmanto, W. & Wahyuningsih, S.P.A. 2020. Detection of Staphylococcus aureus in wound infection on the skin surface. IOP Conf. Series: Earth and Environmental Science 456: 12-21.
Glat, P.M. & Longaker, M.T. 1997. Wound healing. In: Aston SJ, Beasley RW, Thorne CHM eds. Grabb and Smith’s Plastic Surgery, 5th Ed. Philadelphia: Lippincott-Raven 3-12.
Hicks, J. 2018. Fish skin healed bears' paws burned in the California fires. 133 p.
Laikakos, T.; Thornakos, N. & Fine, P.M. 2001. Peritoneal adhesions: Etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Digestive Surgery 18: 260-273.
Lima-Junior, E.M.; Filho, M.O.D.; Costa, B.A.; Fechine, F.V.; De Moraes, M.E.A.; Silva-Junior, F.R.; Soares, M.F.A.D.; Rocha, M.B.S. & Leontsinis, C.M.P. 2019. Innovative treatment using tilapia skin as a xenograft for partial thickness burns after a gunpowder explosion. Journal of Surgical Case Reports 6: 1-4.
Lu, Y.; Liu, P.; Fu, P.; Chen, Y.; Nan, D. & Yang, X. 2017. Comparison of the DWI and Gd-EOB-DTPA-enhanced MRI on assessing the hepatic ischemia and reperfusion injury after partial hepatectomy. Biomedicine & Pharmacotherapy 86: 118-126.
Luna, L.G. 1968. Manual of Histological Staining Methods of the Armed Forces Institute of Pathology, 3rd ed., Mc Graw Hill Book Company. 59 p.
Montero, P. & Gómez-Guillén, M.C. 2000. Extracting conditions for megrim (Lepidorhombus boscii) skin collagen affect functional properties of the resultant gelatin. Journal of Food Science 65: 434-438.
Nakajima, J.; Sasaki, A.; Toru-obuchi, T.; Baba, S.; Nittaand, H. & Wakabayashi, C. 2009. Laparoscopic Subtotal Cholecystactomy for severe Cholecystitis. Surgery Today 39(10): 870-875
Tokajian, S. 2014. New epidemiology of Staphylococcus aureus infections in the Middle East. Clinical Microbiology and Infection 20(7): 624-628.
Verma, G.R.; Lyngdoh, T.S. & Kaman, L. 2006. Placement of 0.5% bupivacaine-soaked surgical in the gallbladder bed is effective for pain after laparoscopic cholecystectomy. Surgical Endoscopy 20: 1560-1564.