Antioxidant benefit of olive leaves extract on arthritis disease induced experimentally in rats

Ishtar Adnan Mohammed ALETHARI, Zainab Ibrahim MOHAMMED, Nawras Majeed HAMMED

Abstract

The aim of this study was to investigate the effects of olive leaves extract on paw thickness, TNF-α, IL-6, RF, bilirubin, albumin and MDA in male albino rates with arthritis and compare it with Naproxen drug. A total of 12 mature male albino rates were divided into four groups, as 3 male rates for each group, and the experiment continued for 14 days. The animals were divided as follow: G1: treated as negative control group, injected with 0.1ml/ physiological normal saline (0.9% Nacl) in the first and third day of the experiment, G2: treated as positive control injected with 0.1 ml/ animal of formaldehyde (2%) in the first and third day of the experiment (Arthritis group), T1: as arthritis group, treated with olive leaf extract orally as 45mg/kg of B.W once daily and T2: as arthritis group, treated with Naproxen tablet orally as 100mg/ kg of B.W once daily. The results showed a significant increase in the paw thickness, TNF-α, IL-6, RF, bilirubin, albumin and MDA in the positive control compared with the negative control group and others groups. The results also showed a significant decrease in the paw thickness, TNF-α, IL-6RF, bilirubin, albumin and MDA in the T1 and T2. Also the results showed a significant decrease in the paw thickness, TNF-α, IL-6, RF, bilirubin, albumin and MDA in T2 group compared with T1. The present study showed that olive leaves extract attenuates Rheumatoid arthritis to be developed by reducing the levels of TNF-α, IL-6, RF, MDA, bilirubin and albumin and its extract was being more safety from Naproxen drug because the adverse effects of Naproxen drug.

Keywords

Antioxidant, Olive Leaves extract, Arthritis disease, Rat.

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References

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