Main Article Content
Abstract
This study includes synthesis, characterization three series of the new derivatives via schiff bases for ampicillin which known as a high medicinal effectiveness. Series A include preparation schiff bases (A1-A6) by condensation of ampicillin with many substituted aldehyedes, while series B include preparation of six amines (B1-B6) is hydrazine hydrate derivatives by reaction schiff bases compounds which prepared in series A with hydrazine hydrate, then series C included for preparation of new six polymers C1-C6 by reaction of poly methyl methacrylate with amine compounds which prepared in series B. The synthesized polymers were identified by spectroscopic methods (FT-IR and 1H-NMR) and measurement some of its physical characteristics.
Keywords
Ampicillin drug
Schiff bases
Poly methyl methacrylate.
Article Details
License
The authors transfer the copyrights of their papers to the Iranian Society of Ichthyology. However, the information could be used in accordance with the Creative Commons licence (Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
How to Cite
KHAMMAS, S. J., MAHMOOD, T. A., YOUSIF, S. A., SADIQ, A. S., MAHMOOD, W. abdul R., & FADEL, Z. H. (2021). Synthesis and characteristic of new polyamides via schiff bases derived from ampicillin. Iranian Journal of Ichthyology, 8, 222–232. Retrieved from http://www.ijichthyol.org/index.php/iji/article/view/010031
References
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Al Zoubi, W. 2013. Biological activities of Schiff bases and their complexes: a review of recent works. International Journal of Organic Chemistry.
AlTamiemi, E.O.: Khammas, S.J. & AlKaissi, S.S. 2016. Synthesis and Characterization of Some New Morpholine Derivatives. Baghdad Science Journal 13(2).
Bala, V.; Chhonker, Y.S. & Hashim, S.R. 2010. Synthesis and antimicrobial activity of Schiff bases derived from 2-formylphenoxy acetic acid. Asian Journal of Chemistry 22(5): 3447.
Gwaram, N.S. & Hassandarvish, P. 2014. Synthesis, characterization and anticancer studies of some morpholine derived Schiff bases and their metal complexes. Journal of Applied Pharmaceutical Science 4(10): 075-080.
Jalhan, S.; Jindal, A.; Gupta, A. & Hemraj, H. 2013. Synthesis, biological activities and chemistry of thiadiazole derivatives and Schiff bases. ChemInform, 44(16).
Kalaivani, S.; Priya, N.P. & Arunachalam, S. 2012. Schiff bases: facile synthesis, spectral characterization and biocidal studies. International Journal of Applied Biology and Pharmaceutical Technology 3: 219-23.
Katarzyna, B. & Eizbieta, L. 2014,"Schiff bases interesting range of applications in various fields of science Institute of General Food chemistry 68(2): 129-134.
Kaushal, R.; Sheetal, R.K. & Nehra, K. 2014. Syntheses, characterizations and biological screening of titanium (iv) complexes derived from antibiotic drug (s). International Journal of Pharmacy and Pharmaceutical Sciences 6: 374-378.
Khammas, J.K. 2012. Synthesis and Characterization of (Oxazep, Diazepine, Tetrazole) for Derivatives of Sulfamethoxazole Drug. Tikrit Journal of Pure Sciences 17(4):84-96.
Kobayashi, S. & Müllen, K. (Eds.). 2015. Encyclopedia of polymeric nanomaterials. Springer Berlin Heidelberg.
Mahmood, T.A. 2015. Synthesis of new N-Substituted-3-chloro-2-azetidinones for 2, 4-Diamino-6-phenyl-1, 3, 5-triazine. Journal of the College of Basic Education 21.
Nandurbar, A.D. 2013. Schiff’s bases and amides of selected five membered heterocyclic compounds: A review. Journal of Chemical and Pharmaceutical Research 5(6): 14-25.
Oledzka, E.; Sobczak, M.; Nalecz-Jawecki, G.; Skrzypczak, A. & Kolodziejski, W. 2014. Ampicillin-ester bonded branched polymers: characterization, cyto-, genotoxicity and controlled drug-release behaviour. Molecules 19(6): 7543-7556.
Priti, Y.; Anjana, S. & Amit, K. 2019. Synthesis and biological activities of schiff bases and their derivatives: a review of recent work", Journal of Basic and Applied Engineering Research 6(1): 62-65.
Reis, C.P.; Neufeld, R.J.; Ribeiro, A.J. & Veiga, F. 2006. Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine 2(1): 8-21.
Savalia, R.V.; Patel, A.P.; Trivedi, P.T.; Gohel, H.R. & Khetani, D.B. 2013. Rapid and economic synthesis of Schiff base of salicylaldehyde by microwave irradiation. Research Journal of Chemical Sciences.
Saxena, A.; Rao, V.L.; Prabhakaran, P.V. & Ninan, K.N. 2003. Synthesis and characterization of polyamides and poly (amide–imide) s derived from 2, 2-bis (4-aminophenoxy) benzonitrile. European Polymer Journal 39(2): 401-405.
Sweaha, Z.J. & Auribieb, M.A.B. 2020. Synthesis and Antibacterial Activity of Schiff Base Compounds Derived from Glyoxal, Vanillin with Their Complexes with Iron (ш).
Udaysinha, P.; Asif, K.; Aarfi, N.; Mustapha, M. & Ramesh Y. 2018. Synthesis and Antibacterial Studies of Some Reduced Schiff Base Derivatives. Oriental Journal of Chemistry 34(6): 2796-2805.
Xavier, A. & Srividhya, N. 2014, "Synthesis and study of Schiff base ligands. Journal of Applied Chemistry 7(11): 06-15.
Zainab, H. & Emad Yand, C. 2014. Synthesis and characterization of Sciff Base of sulfomethoxazole. Organic and Medicinal Chemistry Letters 4:1.
Zulfiqar, S.; Ishaq, M. & Ilyas Sarwar, M. 2010. Synthesis and characterization of soluble aromatic–aliphatic polyamide. Advances in Polymer Technology 29(4): 300-308.
References
Al Zoubi, W. 2013. Biological activities of Schiff bases and their complexes: a review of recent works. International Journal of Organic Chemistry.
AlTamiemi, E.O.: Khammas, S.J. & AlKaissi, S.S. 2016. Synthesis and Characterization of Some New Morpholine Derivatives. Baghdad Science Journal 13(2).
Bala, V.; Chhonker, Y.S. & Hashim, S.R. 2010. Synthesis and antimicrobial activity of Schiff bases derived from 2-formylphenoxy acetic acid. Asian Journal of Chemistry 22(5): 3447.
Gwaram, N.S. & Hassandarvish, P. 2014. Synthesis, characterization and anticancer studies of some morpholine derived Schiff bases and their metal complexes. Journal of Applied Pharmaceutical Science 4(10): 075-080.
Jalhan, S.; Jindal, A.; Gupta, A. & Hemraj, H. 2013. Synthesis, biological activities and chemistry of thiadiazole derivatives and Schiff bases. ChemInform, 44(16).
Kalaivani, S.; Priya, N.P. & Arunachalam, S. 2012. Schiff bases: facile synthesis, spectral characterization and biocidal studies. International Journal of Applied Biology and Pharmaceutical Technology 3: 219-23.
Katarzyna, B. & Eizbieta, L. 2014,"Schiff bases interesting range of applications in various fields of science Institute of General Food chemistry 68(2): 129-134.
Kaushal, R.; Sheetal, R.K. & Nehra, K. 2014. Syntheses, characterizations and biological screening of titanium (iv) complexes derived from antibiotic drug (s). International Journal of Pharmacy and Pharmaceutical Sciences 6: 374-378.
Khammas, J.K. 2012. Synthesis and Characterization of (Oxazep, Diazepine, Tetrazole) for Derivatives of Sulfamethoxazole Drug. Tikrit Journal of Pure Sciences 17(4):84-96.
Kobayashi, S. & Müllen, K. (Eds.). 2015. Encyclopedia of polymeric nanomaterials. Springer Berlin Heidelberg.
Mahmood, T.A. 2015. Synthesis of new N-Substituted-3-chloro-2-azetidinones for 2, 4-Diamino-6-phenyl-1, 3, 5-triazine. Journal of the College of Basic Education 21.
Nandurbar, A.D. 2013. Schiff’s bases and amides of selected five membered heterocyclic compounds: A review. Journal of Chemical and Pharmaceutical Research 5(6): 14-25.
Oledzka, E.; Sobczak, M.; Nalecz-Jawecki, G.; Skrzypczak, A. & Kolodziejski, W. 2014. Ampicillin-ester bonded branched polymers: characterization, cyto-, genotoxicity and controlled drug-release behaviour. Molecules 19(6): 7543-7556.
Priti, Y.; Anjana, S. & Amit, K. 2019. Synthesis and biological activities of schiff bases and their derivatives: a review of recent work", Journal of Basic and Applied Engineering Research 6(1): 62-65.
Reis, C.P.; Neufeld, R.J.; Ribeiro, A.J. & Veiga, F. 2006. Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine 2(1): 8-21.
Savalia, R.V.; Patel, A.P.; Trivedi, P.T.; Gohel, H.R. & Khetani, D.B. 2013. Rapid and economic synthesis of Schiff base of salicylaldehyde by microwave irradiation. Research Journal of Chemical Sciences.
Saxena, A.; Rao, V.L.; Prabhakaran, P.V. & Ninan, K.N. 2003. Synthesis and characterization of polyamides and poly (amide–imide) s derived from 2, 2-bis (4-aminophenoxy) benzonitrile. European Polymer Journal 39(2): 401-405.
Sweaha, Z.J. & Auribieb, M.A.B. 2020. Synthesis and Antibacterial Activity of Schiff Base Compounds Derived from Glyoxal, Vanillin with Their Complexes with Iron (ш).
Udaysinha, P.; Asif, K.; Aarfi, N.; Mustapha, M. & Ramesh Y. 2018. Synthesis and Antibacterial Studies of Some Reduced Schiff Base Derivatives. Oriental Journal of Chemistry 34(6): 2796-2805.
Xavier, A. & Srividhya, N. 2014, "Synthesis and study of Schiff base ligands. Journal of Applied Chemistry 7(11): 06-15.
Zainab, H. & Emad Yand, C. 2014. Synthesis and characterization of Sciff Base of sulfomethoxazole. Organic and Medicinal Chemistry Letters 4:1.
Zulfiqar, S.; Ishaq, M. & Ilyas Sarwar, M. 2010. Synthesis and characterization of soluble aromatic–aliphatic polyamide. Advances in Polymer Technology 29(4): 300-308.
AlTamiemi, E.O.: Khammas, S.J. & AlKaissi, S.S. 2016. Synthesis and Characterization of Some New Morpholine Derivatives. Baghdad Science Journal 13(2).
Bala, V.; Chhonker, Y.S. & Hashim, S.R. 2010. Synthesis and antimicrobial activity of Schiff bases derived from 2-formylphenoxy acetic acid. Asian Journal of Chemistry 22(5): 3447.
Gwaram, N.S. & Hassandarvish, P. 2014. Synthesis, characterization and anticancer studies of some morpholine derived Schiff bases and their metal complexes. Journal of Applied Pharmaceutical Science 4(10): 075-080.
Jalhan, S.; Jindal, A.; Gupta, A. & Hemraj, H. 2013. Synthesis, biological activities and chemistry of thiadiazole derivatives and Schiff bases. ChemInform, 44(16).
Kalaivani, S.; Priya, N.P. & Arunachalam, S. 2012. Schiff bases: facile synthesis, spectral characterization and biocidal studies. International Journal of Applied Biology and Pharmaceutical Technology 3: 219-23.
Katarzyna, B. & Eizbieta, L. 2014,"Schiff bases interesting range of applications in various fields of science Institute of General Food chemistry 68(2): 129-134.
Kaushal, R.; Sheetal, R.K. & Nehra, K. 2014. Syntheses, characterizations and biological screening of titanium (iv) complexes derived from antibiotic drug (s). International Journal of Pharmacy and Pharmaceutical Sciences 6: 374-378.
Khammas, J.K. 2012. Synthesis and Characterization of (Oxazep, Diazepine, Tetrazole) for Derivatives of Sulfamethoxazole Drug. Tikrit Journal of Pure Sciences 17(4):84-96.
Kobayashi, S. & Müllen, K. (Eds.). 2015. Encyclopedia of polymeric nanomaterials. Springer Berlin Heidelberg.
Mahmood, T.A. 2015. Synthesis of new N-Substituted-3-chloro-2-azetidinones for 2, 4-Diamino-6-phenyl-1, 3, 5-triazine. Journal of the College of Basic Education 21.
Nandurbar, A.D. 2013. Schiff’s bases and amides of selected five membered heterocyclic compounds: A review. Journal of Chemical and Pharmaceutical Research 5(6): 14-25.
Oledzka, E.; Sobczak, M.; Nalecz-Jawecki, G.; Skrzypczak, A. & Kolodziejski, W. 2014. Ampicillin-ester bonded branched polymers: characterization, cyto-, genotoxicity and controlled drug-release behaviour. Molecules 19(6): 7543-7556.
Priti, Y.; Anjana, S. & Amit, K. 2019. Synthesis and biological activities of schiff bases and their derivatives: a review of recent work", Journal of Basic and Applied Engineering Research 6(1): 62-65.
Reis, C.P.; Neufeld, R.J.; Ribeiro, A.J. & Veiga, F. 2006. Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine 2(1): 8-21.
Savalia, R.V.; Patel, A.P.; Trivedi, P.T.; Gohel, H.R. & Khetani, D.B. 2013. Rapid and economic synthesis of Schiff base of salicylaldehyde by microwave irradiation. Research Journal of Chemical Sciences.
Saxena, A.; Rao, V.L.; Prabhakaran, P.V. & Ninan, K.N. 2003. Synthesis and characterization of polyamides and poly (amide–imide) s derived from 2, 2-bis (4-aminophenoxy) benzonitrile. European Polymer Journal 39(2): 401-405.
Sweaha, Z.J. & Auribieb, M.A.B. 2020. Synthesis and Antibacterial Activity of Schiff Base Compounds Derived from Glyoxal, Vanillin with Their Complexes with Iron (ш).
Udaysinha, P.; Asif, K.; Aarfi, N.; Mustapha, M. & Ramesh Y. 2018. Synthesis and Antibacterial Studies of Some Reduced Schiff Base Derivatives. Oriental Journal of Chemistry 34(6): 2796-2805.
Xavier, A. & Srividhya, N. 2014, "Synthesis and study of Schiff base ligands. Journal of Applied Chemistry 7(11): 06-15.
Zainab, H. & Emad Yand, C. 2014. Synthesis and characterization of Sciff Base of sulfomethoxazole. Organic and Medicinal Chemistry Letters 4:1.
Zulfiqar, S.; Ishaq, M. & Ilyas Sarwar, M. 2010. Synthesis and characterization of soluble aromatic–aliphatic polyamide. Advances in Polymer Technology 29(4): 300-308.