Main Article Content
Abstract
This study examined the effect of green tea extract and metformin on diabetic mellitus in male rats. Based on the result, green-tea oral admistration (300 mg/kg body weight) showed a reduction in plasma glucose, glycosylated hemoglobin (HbA1c) and hemoglobin and insulin levels in diabetic rates in 30 days. The oral administration of green tea extracts in diabetic male rates caused the glycogen creation utilizing proteins by building the remainder of the cells to deliver more insulin. As conclusions, green tea has an effect comparable to that of metformin on diabetic patients.
Keywords
Green tea
Metformin
Diabetic Mellitus
Straptozotocin.
Article Details
License
The authors transfer the copyrights of their papers to the Iranian Society of Ichthyology. However, the information could be used in accordance with the Creative Commons licence (Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
How to Cite
OUDAH, K. H., HAMMOODI, H. A., & NAJM, M. A. (2021). The effect of green tea extract and metformin on diabetic mellitus induce in male rats. Iranian Journal of Ichthyology, 8, 163–167. Retrieved from http://www.ijichthyol.org/index.php/iji/article/view/010023
References
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AL-Badry, S.H.; Khalaf, S.A.; AL-Khuzaiy, A.L.I.A. & Roomi, A. 2020. The effects of irisin on the transforming growth factor-beta1 (TGF-β1) level in type-1 diabetic patients in Thi-Qar province. International Journal of Pharmaceutical Research 12(4).
Alberti, K.G.M.M. 1982. The Biochemistry and the Complications of Diabetes. In: Keen, H., Jarrett, J. (Eds.), Complications of Diabetes, vol. 43. Edward Arnold Press, London. pp: 23-1270.
Blumenberg, A.; Benabbas, R.; Sinert, R.; Jeng, A.; & Wiener, S.W. 2020. Do patients die with or from metformin-associated lactic acidosis (MALA)? Systematic review and meta-analysis of pH and lactate as predictors of mortality in MALA. Journal of Medical Toxicology 16(2): 222-229.
Guariguata, L.; Whiting, D.R.; Hambleton, I.; Beagley, J.; Linnenkamp, U. & Shaw, J.E. 2014. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice 103: 137-149.
Kobayashi, Y.; Suzuki, M.; Satsu, H.; Arai, S.; Hara, Y.; Suzuki, K. & Shimizu, M. 2000. Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. Journal of Agricultural and Food Chemistry 48(11): 5618-5623.
Li, F.; Li, S.; Li, H.-B.; Deng, G.-F.; Ling, W.-H. & Xu, X.-R. 2013. Antiproliferative activities of tea and herbal infusions. Food and Function 4: 530-538.
Li, S.; Gan, L.-Q.; Li, S.-K.; Zheng, J.-C.; Xu, D.-P. & Li, H.-B. 2014. Effects of herbal infusions, tea and carbonated beverages on alcohol dehydrogenase and aldehyde dehydrogenase activity. Food and Function 5: 42-49.
Maruthur, N.M.; Tseng, E.; Hutfless, S.; Wilson, L.M.; Suarez-Cuervo, C.; Berger, Z.; Chu, Y.; Iyoha, E.; Segal, J. & Bolen, B. 2016. Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis. Annals of Internal Medicine 164(11): 740-751.
Pederson, B.A.; Schroeder, J.M.; Parker, G.; Smith, M.W.; DePaoli-Roach, A.A. & Roach, P.J. 2005. Glucose metabolism in mice lacking muscle glycogen synthase. Diabetes 54: 3466-3473.
Qasim, M.T. & Al-Mayali, H.K. 2019a. Investigate the relation between Baicalin effect and gene expression of LH, FSH, Testosterone in male rats treated with Gemcitabine drug. Research Journal of Pharmacy and Technology 12(9): 4135-4141.
Qasim, M.T. & Al-Mayali, H.K. 2019b. The immunological and protective role of baicalin in male rats treated with chemotherapy (Gemcitabine). Journal of Physics 1234(1): 012065.
Roomi, A.B.; AL-Salih R.M. & Ali, S.A. 2019. Impact metformin and insulin therapy on parathyroid hormone and 25 (OH) vitamin D in diabetic post-menopausal Iraqi women. Journal of Physics 1279(1): 012008.
Roomi, A.B.; AL-Salih, R.M. & Ali, S.A. 2019. The effect insulin therapy and metformin on osteoporosis in diabetic post-menopausal Iraqi women. Indian Journal of Public Health Research and Development 10(4): 1544-1549.
Shaw, J.E.; Sicree, R.A. & Zimmet, P.Z. 2010. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice 87: 4-14.
Triggle, C.R. & Ding, H. 2017. Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium. Acta Physiologica 219(1): 138-151.
Whiting, D.R.; Guariguata, L.; Weil, C. & Shaw, J. 2011. IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Research and Clinical Practice 94: 311-321.
Wu, L.Y.; Juan, C.C.; Ho, L.T.; Hsu, Y.P. & Hwang, L.S. 2004. Effect of green tea supplementation on insulin sensitivity in Sprague−Dawley rats. Journal of Agricultural and Food Chemistry 52(3): 643-648.
References
AL-Badry, S.H.; Khalaf, S.A.; AL-Khuzaiy, A.L.I.A. & Roomi, A. 2020. The effects of irisin on the transforming growth factor-beta1 (TGF-β1) level in type-1 diabetic patients in Thi-Qar province. International Journal of Pharmaceutical Research 12(4).
Alberti, K.G.M.M. 1982. The Biochemistry and the Complications of Diabetes. In: Keen, H., Jarrett, J. (Eds.), Complications of Diabetes, vol. 43. Edward Arnold Press, London. pp: 23-1270.
Blumenberg, A.; Benabbas, R.; Sinert, R.; Jeng, A.; & Wiener, S.W. 2020. Do patients die with or from metformin-associated lactic acidosis (MALA)? Systematic review and meta-analysis of pH and lactate as predictors of mortality in MALA. Journal of Medical Toxicology 16(2): 222-229.
Guariguata, L.; Whiting, D.R.; Hambleton, I.; Beagley, J.; Linnenkamp, U. & Shaw, J.E. 2014. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice 103: 137-149.
Kobayashi, Y.; Suzuki, M.; Satsu, H.; Arai, S.; Hara, Y.; Suzuki, K. & Shimizu, M. 2000. Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. Journal of Agricultural and Food Chemistry 48(11): 5618-5623.
Li, F.; Li, S.; Li, H.-B.; Deng, G.-F.; Ling, W.-H. & Xu, X.-R. 2013. Antiproliferative activities of tea and herbal infusions. Food and Function 4: 530-538.
Li, S.; Gan, L.-Q.; Li, S.-K.; Zheng, J.-C.; Xu, D.-P. & Li, H.-B. 2014. Effects of herbal infusions, tea and carbonated beverages on alcohol dehydrogenase and aldehyde dehydrogenase activity. Food and Function 5: 42-49.
Maruthur, N.M.; Tseng, E.; Hutfless, S.; Wilson, L.M.; Suarez-Cuervo, C.; Berger, Z.; Chu, Y.; Iyoha, E.; Segal, J. & Bolen, B. 2016. Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis. Annals of Internal Medicine 164(11): 740-751.
Pederson, B.A.; Schroeder, J.M.; Parker, G.; Smith, M.W.; DePaoli-Roach, A.A. & Roach, P.J. 2005. Glucose metabolism in mice lacking muscle glycogen synthase. Diabetes 54: 3466-3473.
Qasim, M.T. & Al-Mayali, H.K. 2019a. Investigate the relation between Baicalin effect and gene expression of LH, FSH, Testosterone in male rats treated with Gemcitabine drug. Research Journal of Pharmacy and Technology 12(9): 4135-4141.
Qasim, M.T. & Al-Mayali, H.K. 2019b. The immunological and protective role of baicalin in male rats treated with chemotherapy (Gemcitabine). Journal of Physics 1234(1): 012065.
Roomi, A.B.; AL-Salih R.M. & Ali, S.A. 2019. Impact metformin and insulin therapy on parathyroid hormone and 25 (OH) vitamin D in diabetic post-menopausal Iraqi women. Journal of Physics 1279(1): 012008.
Roomi, A.B.; AL-Salih, R.M. & Ali, S.A. 2019. The effect insulin therapy and metformin on osteoporosis in diabetic post-menopausal Iraqi women. Indian Journal of Public Health Research and Development 10(4): 1544-1549.
Shaw, J.E.; Sicree, R.A. & Zimmet, P.Z. 2010. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice 87: 4-14.
Triggle, C.R. & Ding, H. 2017. Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium. Acta Physiologica 219(1): 138-151.
Whiting, D.R.; Guariguata, L.; Weil, C. & Shaw, J. 2011. IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Research and Clinical Practice 94: 311-321.
Wu, L.Y.; Juan, C.C.; Ho, L.T.; Hsu, Y.P. & Hwang, L.S. 2004. Effect of green tea supplementation on insulin sensitivity in Sprague−Dawley rats. Journal of Agricultural and Food Chemistry 52(3): 643-648.
Alberti, K.G.M.M. 1982. The Biochemistry and the Complications of Diabetes. In: Keen, H., Jarrett, J. (Eds.), Complications of Diabetes, vol. 43. Edward Arnold Press, London. pp: 23-1270.
Blumenberg, A.; Benabbas, R.; Sinert, R.; Jeng, A.; & Wiener, S.W. 2020. Do patients die with or from metformin-associated lactic acidosis (MALA)? Systematic review and meta-analysis of pH and lactate as predictors of mortality in MALA. Journal of Medical Toxicology 16(2): 222-229.
Guariguata, L.; Whiting, D.R.; Hambleton, I.; Beagley, J.; Linnenkamp, U. & Shaw, J.E. 2014. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice 103: 137-149.
Kobayashi, Y.; Suzuki, M.; Satsu, H.; Arai, S.; Hara, Y.; Suzuki, K. & Shimizu, M. 2000. Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. Journal of Agricultural and Food Chemistry 48(11): 5618-5623.
Li, F.; Li, S.; Li, H.-B.; Deng, G.-F.; Ling, W.-H. & Xu, X.-R. 2013. Antiproliferative activities of tea and herbal infusions. Food and Function 4: 530-538.
Li, S.; Gan, L.-Q.; Li, S.-K.; Zheng, J.-C.; Xu, D.-P. & Li, H.-B. 2014. Effects of herbal infusions, tea and carbonated beverages on alcohol dehydrogenase and aldehyde dehydrogenase activity. Food and Function 5: 42-49.
Maruthur, N.M.; Tseng, E.; Hutfless, S.; Wilson, L.M.; Suarez-Cuervo, C.; Berger, Z.; Chu, Y.; Iyoha, E.; Segal, J. & Bolen, B. 2016. Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis. Annals of Internal Medicine 164(11): 740-751.
Pederson, B.A.; Schroeder, J.M.; Parker, G.; Smith, M.W.; DePaoli-Roach, A.A. & Roach, P.J. 2005. Glucose metabolism in mice lacking muscle glycogen synthase. Diabetes 54: 3466-3473.
Qasim, M.T. & Al-Mayali, H.K. 2019a. Investigate the relation between Baicalin effect and gene expression of LH, FSH, Testosterone in male rats treated with Gemcitabine drug. Research Journal of Pharmacy and Technology 12(9): 4135-4141.
Qasim, M.T. & Al-Mayali, H.K. 2019b. The immunological and protective role of baicalin in male rats treated with chemotherapy (Gemcitabine). Journal of Physics 1234(1): 012065.
Roomi, A.B.; AL-Salih R.M. & Ali, S.A. 2019. Impact metformin and insulin therapy on parathyroid hormone and 25 (OH) vitamin D in diabetic post-menopausal Iraqi women. Journal of Physics 1279(1): 012008.
Roomi, A.B.; AL-Salih, R.M. & Ali, S.A. 2019. The effect insulin therapy and metformin on osteoporosis in diabetic post-menopausal Iraqi women. Indian Journal of Public Health Research and Development 10(4): 1544-1549.
Shaw, J.E.; Sicree, R.A. & Zimmet, P.Z. 2010. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice 87: 4-14.
Triggle, C.R. & Ding, H. 2017. Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium. Acta Physiologica 219(1): 138-151.
Whiting, D.R.; Guariguata, L.; Weil, C. & Shaw, J. 2011. IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Research and Clinical Practice 94: 311-321.
Wu, L.Y.; Juan, C.C.; Ho, L.T.; Hsu, Y.P. & Hwang, L.S. 2004. Effect of green tea supplementation on insulin sensitivity in Sprague−Dawley rats. Journal of Agricultural and Food Chemistry 52(3): 643-648.