Main Article Content

Abstract

Globally animal models play very important role in the progress of life science in a wide range of biological experimentations. Suitability of different animal model relies on its similarity in genetic makeup, resemble physiological response on diseases of multiple etiology and different drugs, easy maintenance of model animal. Among the fishes, zebrafish and some other species like killifish and cave fish has been found to have great potential and being experimented as an alternative model animal for experimentation of some specific human diseases. Metadata analysis with relevant keywords revealed >8000 research publications on fish model in last 12 years. In India, zebrafish, Danio rerio (Hamilton, 1822), is widely distributed. However, very less attention has so far been paid to understand the importance of the species in biological experimentation except few scattered reports. Besides zebrafish, use of African killifish and cave fish has also been outlined. The present paper synthesized the current knowledge of research and discussed the status and potentials of fish as a model in modern biological experimentation in various medical disorders and recommends their utilization for drug discovery and critical human disease modelling.

Keywords

Danio rerio Killifish Metadata Biomedical research.

Article Details

Author Biographies

Asit Kumar BERA, ICAR- Central Inland Fisheries Research Institute, Barrackpore, Kolkata- 700120, India.

Division of Reservoir and Wetland Fisheries, Principal Scientist

Uttam Kumar SARKAR, ICAR- Central Inland Fisheries Research Institute, Barrackpore, Kolkata- 700120, India.

Division of Reservoir and Wetland Fisheries, Principal Scientist and Head

Debendra Nath DEY, Bexel Pharmaceuticals, Inc., 32990 Alvarado-Niles Road, Suite 910, Union City, CA, USA.

Research and Product Development, Scientist

Sadrupa BHOWMICK, ICAR- Central Inland Fisheries Research Institute, Barrackpore, Kolkata- 700120, India.

Division of Reservoir and Wetland Fisheries, Technical Assistant

Basanta Kumar DAS, ICAR- Central Inland Fisheries Research Institute, Barrackpore, Kolkata- 700120, India.

ICAR- Central Inland Fisheries Research Institute

Director

How to Cite
BERA, A. K., SARKAR, U. K., DEY, D. N., BHOWMICK, S., & DAS, B. K. (2020). Use of fish model in modern biological experimentation: Synthesis and review. Iranian Journal of Ichthyology, 7(4), 280–297. https://doi.org/10.22034/iji.v7i4.527

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