Main Article Content
Abstract
Dental infection affects most people especially those without sufficient dental care. This infection occurs when bacteria occupy the pulp area and surrounding tissues due to factors such as trauma and dental procedures. Dental infections may activate malignant transformation in most of the tissues related to the mouth and other organs. Dental caries and periodontal diseases are considered as top oral health diseases in the world. This study focuses on the molecular docking of target protein with FDA approved drugs for the identification of potent inhibitor. Therefore, we used different computational approaches to target protein structures of Interleukin-1 receptor, type1 (IL1R1). The ligands and bio-ceramic chemical compounds are docked against the IL1R1 protein and the results indicate a better affinity for specific compounds. Moreover, the interaction analysis is also carried out on the best-docked compounds with target protein which can be helpful for the identification of a lead compound that can treat dental infections effectively.
Keywords
IL1R1
Bio-ceramic
Teeth infections
CADD
Tetracycline.
Article Details
License
The authors transfer the copyrights of their papers to the Iranian Society of Ichthyology. However, the information could be used in accordance with the Creative Commons licence (Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
How to Cite
JAZZAA, N. T., TURKI, M. M., SHABAN, S. A., & SULEIMAN, A. A. (2021). Identification of interaction of potent inhibitors against dental infections and bio-ceramics with IL1R1 through molecular docking of drug designing. Iranian Journal of Ichthyology, 8, 274–279. Retrieved from http://www.ijichthyol.org/index.php/iji/article/view/010037
References
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Robertson, D. & A. Smith 2009. The microbiology of the acute dental abscess. Journal of medical microbiology 58(2): 155-162.
Patini, R. 2020. Personalized Dentistry: Approaching a New Way for Diagnosis and Treatment of Oral Diseases, Multidisciplinary Digital Publishing. Journal of Personalized Medicine 10(2): 35.
Hassan, S.A. 2020. Effect of illicit drugs on dental health-A. IP International Journal of Comprehensive and Advanced Pharmacolog 5(3): 105-109
Virtanen, E. 2014. History of dental infections associates with cancer in periodontally healthy subjects: a 24-year follow-up study from Sweden. Journal of Cancer 5(2): 79.
Söder, B. 2012. The association of dental plaque with cancer mortality in Sweden. A longitudinal study. BMJ Open 2(3).
Rosan, B. & Lamont, R.J. 2000. "Dental plaque formation." Microbes and Infection 2(13): 1599-1607.
Tezal, M. 2013. Dental caries and head and neck cancers." JAMA Otolaryngology– Head & Neck Surgery 139(10): 1054-1060.
Dave, M. 2020. Challenges in plain film radiographic diagnosis for the dental team: a review of the maxillary sinus. British Dental Journal 228(8): 587-594.
Benjumeda, W.I. 2020. "Analysis of cell-biomaterial interaction through cellular bridge formation in the interface between hGMSCs and CaP bioceramics. Scientific Reports (Nature Publisher Group) 10(1).
Raghavan, R. 2020. Bioceramics: Dental Implant Biomaterials. The Journal of Prosthetic and Implant Dentistry 4(1).
Zhong, S. 2017. Viral microRNAs identified in human dental pulp. Journal of Endodontics 43(1): 84-89.
Aral, C.A.; Dilber, E.; Aral, K., Sarica, Y. & Sivrikoz, O.N. 2015. Management of cyclosporine and nifedipine-induced gingival hyperplasia. Journal of Clinical and Diagnostic Research: JCDR 9(12): ZD12.
Petrovski, M. & Terzieva-Petrovska, O. 2020. The most common used antibiotic drugs among dental medicine doctors. Macedonian Pharmaceutical Bulletin 66 (Suppl.1): 65-66.
Larsen, T. & Fiehn, N.E. 2017. Dental biofilm infections–an update. Apmis 125(4): 376-384.
Juntavee, N. 2018. "Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration. International Journal of Nanomedicine 13: 2755.
Obaidat, R.M. 2011. Preparation of mucoadhesive oral patches containing tetracycline hydrochloride and carvacrol for treatment of local mouth bacterial infections and candidiasis. Scientia Pharmaceutica 79(1): 197-212.
References
Robertson, D. & A. Smith 2009. The microbiology of the acute dental abscess. Journal of medical microbiology 58(2): 155-162.
Patini, R. 2020. Personalized Dentistry: Approaching a New Way for Diagnosis and Treatment of Oral Diseases, Multidisciplinary Digital Publishing. Journal of Personalized Medicine 10(2): 35.
Hassan, S.A. 2020. Effect of illicit drugs on dental health-A. IP International Journal of Comprehensive and Advanced Pharmacolog 5(3): 105-109
Virtanen, E. 2014. History of dental infections associates with cancer in periodontally healthy subjects: a 24-year follow-up study from Sweden. Journal of Cancer 5(2): 79.
Söder, B. 2012. The association of dental plaque with cancer mortality in Sweden. A longitudinal study. BMJ Open 2(3).
Rosan, B. & Lamont, R.J. 2000. "Dental plaque formation." Microbes and Infection 2(13): 1599-1607.
Tezal, M. 2013. Dental caries and head and neck cancers." JAMA Otolaryngology– Head & Neck Surgery 139(10): 1054-1060.
Dave, M. 2020. Challenges in plain film radiographic diagnosis for the dental team: a review of the maxillary sinus. British Dental Journal 228(8): 587-594.
Benjumeda, W.I. 2020. "Analysis of cell-biomaterial interaction through cellular bridge formation in the interface between hGMSCs and CaP bioceramics. Scientific Reports (Nature Publisher Group) 10(1).
Raghavan, R. 2020. Bioceramics: Dental Implant Biomaterials. The Journal of Prosthetic and Implant Dentistry 4(1).
Zhong, S. 2017. Viral microRNAs identified in human dental pulp. Journal of Endodontics 43(1): 84-89.
Aral, C.A.; Dilber, E.; Aral, K., Sarica, Y. & Sivrikoz, O.N. 2015. Management of cyclosporine and nifedipine-induced gingival hyperplasia. Journal of Clinical and Diagnostic Research: JCDR 9(12): ZD12.
Petrovski, M. & Terzieva-Petrovska, O. 2020. The most common used antibiotic drugs among dental medicine doctors. Macedonian Pharmaceutical Bulletin 66 (Suppl.1): 65-66.
Larsen, T. & Fiehn, N.E. 2017. Dental biofilm infections–an update. Apmis 125(4): 376-384.
Juntavee, N. 2018. "Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration. International Journal of Nanomedicine 13: 2755.
Obaidat, R.M. 2011. Preparation of mucoadhesive oral patches containing tetracycline hydrochloride and carvacrol for treatment of local mouth bacterial infections and candidiasis. Scientia Pharmaceutica 79(1): 197-212.
Patini, R. 2020. Personalized Dentistry: Approaching a New Way for Diagnosis and Treatment of Oral Diseases, Multidisciplinary Digital Publishing. Journal of Personalized Medicine 10(2): 35.
Hassan, S.A. 2020. Effect of illicit drugs on dental health-A. IP International Journal of Comprehensive and Advanced Pharmacolog 5(3): 105-109
Virtanen, E. 2014. History of dental infections associates with cancer in periodontally healthy subjects: a 24-year follow-up study from Sweden. Journal of Cancer 5(2): 79.
Söder, B. 2012. The association of dental plaque with cancer mortality in Sweden. A longitudinal study. BMJ Open 2(3).
Rosan, B. & Lamont, R.J. 2000. "Dental plaque formation." Microbes and Infection 2(13): 1599-1607.
Tezal, M. 2013. Dental caries and head and neck cancers." JAMA Otolaryngology– Head & Neck Surgery 139(10): 1054-1060.
Dave, M. 2020. Challenges in plain film radiographic diagnosis for the dental team: a review of the maxillary sinus. British Dental Journal 228(8): 587-594.
Benjumeda, W.I. 2020. "Analysis of cell-biomaterial interaction through cellular bridge formation in the interface between hGMSCs and CaP bioceramics. Scientific Reports (Nature Publisher Group) 10(1).
Raghavan, R. 2020. Bioceramics: Dental Implant Biomaterials. The Journal of Prosthetic and Implant Dentistry 4(1).
Zhong, S. 2017. Viral microRNAs identified in human dental pulp. Journal of Endodontics 43(1): 84-89.
Aral, C.A.; Dilber, E.; Aral, K., Sarica, Y. & Sivrikoz, O.N. 2015. Management of cyclosporine and nifedipine-induced gingival hyperplasia. Journal of Clinical and Diagnostic Research: JCDR 9(12): ZD12.
Petrovski, M. & Terzieva-Petrovska, O. 2020. The most common used antibiotic drugs among dental medicine doctors. Macedonian Pharmaceutical Bulletin 66 (Suppl.1): 65-66.
Larsen, T. & Fiehn, N.E. 2017. Dental biofilm infections–an update. Apmis 125(4): 376-384.
Juntavee, N. 2018. "Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration. International Journal of Nanomedicine 13: 2755.
Obaidat, R.M. 2011. Preparation of mucoadhesive oral patches containing tetracycline hydrochloride and carvacrol for treatment of local mouth bacterial infections and candidiasis. Scientia Pharmaceutica 79(1): 197-212.